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>> Protein Variability Server


Protein Variability Server

This server calculates the sequence variability within a multiple sequence alignment using the Shannon entropy measure (H) as the variability metric. For each site in the alignment, H ranges from 0 (only one residue is present at that site) to 4.3 (all 20 residues are equally represented in that site). Following these calculations, the server can perform several optional tasks including mapping the sequence variability onto a provided 3D-structure. For more detail information click here.

INPUT ALIGNMENT

Alignment name:

Choose your input data: Protein Alignment PDB File

Paste your alignment. CLUSTAL format CLUSTAL W (1.81) multiple sequence alignment QUERY1 KWASLWNWFNITNWLWYIK CONSENSUS_A2 KWANLWNWFDISNWLWYIK A_CD_KCC23 KWANLWNWFEISNWLWYIK A_CD_KMST914 KWASLWNWFDISNWLWYIR A_GB_MA2465 KWANLWNWFDITNWLWYIK A_GB_MC1086 KWANLWTWFDISNWLWYIK A_KE_Q1687 KWASLWNWFDISKWLWHIR A_KE_Q2598 KWANLWNWFDISNWLWYIR A_KE_Q4619 KWANLWNWFDISKWLWYIK A_KE_Q76910 KWANLWNWFDISNWLWYIK A_KE_Q84211 KWANLWNWFDISNWLWYIK A_KE_K8912 KWANLWNWFDISNWLWYIK A_RW_PVPI13 KWASLWNWFDISNWLWYIR A1_KE_MSA407232 KWASLWNWFDISNWLWYIK A1_KE_MSA407633 KWANLWNWFNISNWLWYIK A1_KE_MSA407934 KWASLWNWFDISNWLWYIR A1_KE_NKU300535 KWASLWSWFSISKWLWYIK A1_KE_KNH108838 KWASLWNWFDITRWLWYIK A1_KE_KNH113539 KWASLWNWFDISSWLWYIR A1_KE_KSM402140 KWASLWNWFSITNWLWYIR A1_SE_SE725342 KWANLWNWFEITKWLWYIK A1_SE_SE753543 KWTNLWSWFSISNWLWYIR A1_SE_SE853844 KWASLWNWFDISRWLWYIR A1_SE_SE889145 KWANLWNWFDISKWLWYIK A1_SE_UGSE813146 KWANLWNWFDISNWLWYIK A1_TZ_97TZ0247 KWANLWNWFDISKWLWYIR A1_TZ_97TZ0348 KWANLWNWFDITNWLWYIK A1_UA_98UA011649 KWASLWNWFDISNWLWYIK B_AR_ARMA13263 KWASLWNWFDITQWLWYIR B_AU_VH65 KWASLWNWFSITKWLWYIK B_AU_MBC20066 KWASLWNWFDITKWLWYIK B_AU_MBC92567 KWASLWNWFDITNWLWYIK B_AU_MBCC5469 NWASLWNWFDITKWLWYIK B_AU_MBCC9870 KWASLWNWFDITSWLWYIK B_GB_CW01297 KWASLWNWFDITNWLWYIK B_GB_CW037A01598 KWASLWNWFNITHWLWYIK B_GB_CW03799 KWASLWNWFDTTHWLWYIK B_GB_CW048100 EWASLWSWFDITNWLWYIK B_GB_HIM286336101 KWASLWNWFDISNWLWYIK B_GB_M24244C3104 KWASLWNWFDITKWLWYIK B_GB_M26864105 KWASLWNWFSITNWLWYIK B_GB_M30156106 KWASLWNWFSITHWLWYIK B_GB_M737677107 KWASLWNWFDITNWLWYIK B_GB_M737685108 KWASLWSWFSITNWLWYIR B_GB_MB314109 KWASLWNWFSITSWLWYIK B_GB_PE052C1110 KWASLWNWFDITKWLWYIK B_GB_PE101111 KWASLWNWFDITKWLWYIK B_GB_PE104C38112 KWANLWSWFSISNWLWYIK B_GB_PE124113 KWASLWSWFDISNWLWYIR B_GB_PE131C3114 KWASLWSWFSITNWLWYIR
or Upload Alignment (CLUSTAL format)
PDB OPTIONS Get PDB file from PDB code or Upload your PDB File	OPTIONAL SEARCH PARAMETERS Chain ID

VARIABILITY OPTIONS
Select Variability Method Shannon Simpson Wu-Kabat
Select Reference Sequence: Consensus sequence First sequence in alignment

OPTIONAL TASKS

Plot variability

Mask sequence variability

Return conserved fragment of length

Map structural variability

PDB file:

Map structural variability

VARIABILITY THRESHOLD
Enter threshold:

Hits since Dec/2004

Last updated:


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