This server calculates the sequence variability within a multiple sequence alignment using the
Shannon entropy measure (H)
as the variability metric. For each site in the alignment, H ranges from 0 (only one residue is present at that site) to 4.3 (all 20 residues are equally represented in that site).
Following these calculations, the server can perform several optional tasks including mapping the sequence variability onto a provided 3D-structure.
For more detail information click