Structural and cell biology studies often require engineering proteins with enhanced solubility.
This server identifies solvent exposed hydrophobic residues in a protein sequence,
and compares them with those of closely related sequences, providing thus useful help to select
the best residues to be targeted for site-directed mutagenesis.
Note: Altering solvent exposed surface residues can result in loss
of the biological function of a protein. Therefore, the information generated by this tool should
be complemented with any available experimental data.