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>> Proteasome Cleavage Prediction Server
Cleavage models
Immunoproteasome
model 1 (SE 0,906 SP 0,545)
model 2 (SE 0,903 SP 0,407)
model 3 (SE 0,763 SP 0,708)
Proteasome
model 1 (SE 0,855 SP 0,603)
model 2 (SE 0,874 SP 0,534)
model 3 (SE 0,792 SP 0,723)
Threshold
0.1
0.2
0.3
0.4
0.45
0.5
0.55
0.6
0.65
0.7
0.8
0.9
1.0
Input
Replace example sequence with your sequence(s)
>HLAF_HUMAN MAPRSLLLLLSGALALTDTWAGSHSLRYFSTAVSRPGRGEPRYIAVEYVDDTQFLRFDSDAAIPRMEPREPWVEQEGPQYWEWTTGYA KANAQTDRVALRNLLRRYNQSEAGSHTLQGMNGCDMGPDGRLLRGYHQHAYDGKDYISLNEDLRSWTAADTVAQITQRFYEAEEYAEE FRTYLEGECLELLRRYLENGKETLQRADPPKAHVAHHPISDHEATLRCWALGFYPAEITLTWQRDGEEQTQDTELVETRPAGDGTFQK WAAVVVPSGEEQRYTCHVQHEGLPQPLILRWEQSPQPTIPIVGIVAGLVVLGAVVTGAVVAAVMWRKKSSDRNRGSYSQAAVTDSAQG SGVSLTANKV
or Upload sequence(s) from local file
1. Browse File:
2: Load File
OUTPUT
Residues
Cleavage Sites per residue
Peptides
Peptides with Cleavage sites at C-terminus
Size
9
10
11
12
13
14
15
16
Graphics
Filter
Discard Peptides with internal cleavage sites
I-Threshold
0.1
0.2
0.3
0.4
0.45
0.5
0.55
0.6
0.65
0.7
0.8
0.9
1.0
Citation:
Diez-Rivero CM, Lafuente EM, Reche PA. Computational analysis and modeling of cleavage by the immunoproteasome and the constitutive proteasome. BMC Bioinformatics. 2010 Sep 23;11:479. doi: 10.1186/1471-2105-11-479. PMID: 20863374; PMCID: PMC2955702
Gomez-Perosanz M, Ras-Carmona A, Reche PA. PCPS: A Web Server to Predict Proteasomal Cleavage Sites. Methods Mol Biol. 2020;2131:399-406. doi: 10.1007/978-1-0716-0389-5_23. PMID: 32162269.
Gomez-Perosanz M, Ras-Carmona A, Lafuente EM, Reche PA. Identification of CD8+ T cell epitopes through proteasome cleavage site predictions. BMC Bioinformatics. 2020 Dec 14;21(Suppl 17):484. doi: 10.1186/s12859-020-03782-1. PMID: 33308150; PMCID: PMC7733697.
Praises and Complaints:
Pedro A. Reche
Hits since May/2009
Last updated:
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